研究成果(平成22年度)

泊 幸秀

Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.
Iwasaki S, Kobayashi M, Yoda M, Sakaguchi Y, Katsuma S, Suzuki T, *Tomari Y.
Mol Cell. 2010 Jul 30;39(2):292-299. Epub 2010 Jun 3.
[Pubmed] [Press release] [Preview]

Making RISC.
Kawamata T, *Tomari Y.
Trends Biochem Sci. 2010 Jul;35(7):368-76.
[Pubmed]

宮川(倉持) さとみ

MVH in piRNA processing and gene silencing of retrotransposons.
*Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, *Nakano T.
Genes Dev. 2010 May;24(9):887-92.
[Pubmed]

影山 裕二

Small peptides switch the transcriptional activity of Shavenbaby during Drosophila embryogenesis.
Kondo T, Plaza S, Zanet J, Benrabah E, Valenti P, Hashimoto Y, Kobayashi S, *Payre F, *Kageyama Y.
Science. 2010 Jul 16;329(5989):336-9.
[Pubmed] [Press release] [Preview]

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研究成果(平成21年度)

泊 幸秀

ATP-dependent human RISC assembly pathways.
Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q, *Tomari Y.
Nature Structural & Molecular Biology. 2010 Jan;17(1):17-23.
[Pubmed] [Press release]

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.
Kawamata T, Seitz H, *Tomari Y.
Nature Structural & Molecular Biology. 2009 Sep;16(9):953-60.
[Pubmed] [Press release]

程 久美子

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.
*Naito Y, Yoshimura J, Morishita S, *Ui-Tei K.
BMC Bioinformatics. 2009 Nov 30;10:392.
[Pubmed]

中澤 敬信

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.
Taniguchi T, *Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.
The EMBO Journal. 2009 Dec 2;28(23):3717-29. Epub 2009 Oct 15.
[Pubmed]

宮川(倉持) さとみ

Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells.
Kojima K. *Kuramochi-Miyagawa S. Chuma S. Tanaka T. Nakatsuji N. Kimura T. *Nakano T.
Genes to Cells. 2009 Oct;14(10):1155-1165.
[Pubmed]

RNA silencing in germlines--exquisite collaboration of Argonaute proteins with small RNAs for germline survival.
*Siomi MC. Kuramochi-Miyagawa S.
Current Opinion in Cell Biology. 2009 Jun;21(3):426-34
[Pubmed]

竹下 文隆

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes.
Takeshita F, Patrawala L, Osaki M, Takahashi RU, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, *Ochiya T.
Mol Ther. 2010 Jan;18(1):181-7.
[Pubmed]

Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA.
Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, *Ochiya T.
Cancer Gene Ther. 2010 Jan;17(1):1-10.
[Pubmed]

Screening of potential molecular targets for colorectal cancer therapy.
Honma K, Takemasa I, Matoba R, Yamamoto Y, Takeshita F, Mori M, Monden M, Matsubara K, *Ochiya T.
Int J Gen Med. 2009 Dec 29;2:243-57.
[Pubmed]

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